Lung Transplantation

Lung Transplantation

There's a particular kind of exhaustion that patients with end-stage lung disease describe. Not tiredness from exertion, but actual breathlessness while sitting still. Walking to the bathroom becomes an event. Conversations get cut short. Sleep is interrupted by the effort of breathing. By the time most patients seek medical care, they've already tried everything else. Inhalers, steroids, long-term oxygen therapy, and pulmonary rehabilitation. Sometimes, none of it is enough. That's when lung transplantation is considered, not as a last resort in the dismissive sense, but as a genuine, life-restoring option for carefully selected patients.

It is, at its core, a surgical replacement. One or both diseased lungs are removed and replaced with healthy donor lungs, either from a deceased donor or, in rare cases, a living donor contributing a lobe. The goal isn't just survival. Its function matters too. Most patients who successfully undergo transplantation report a quality of life they hadn't experienced in years.

Whether a single or double lung transplant is performed depends on the underlying disease:

  • Single lung transplant - suitable for conditions like pulmonary fibrosis or COPD, particularly in older patients
  • Double lung transplant - preferred for cystic fibrosis or bronchiectasis, where leaving one diseased lung behind could harbour chronic infection that threatens the new one

The choice isn't arbitrary; it's made after extensive evaluation by the transplant team.

Lung transplantation is considered for patients with severe, progressive lung disease that has not responded adequately to medical management. Conditions we see most commonly include:

  • Chronic obstructive pulmonary disease (COPD)
  • Idiopathic pulmonary fibrosis (IPF)
  • Primary pulmonary hypertension
  • Cystic fibrosis
  • Bronchiectasis
  • Interstitial lung diseases

Practically speaking, transplant evaluation is considered when a patient:

  • Becomes dependent on supplemental oxygen
  • Experiences frequent hospitalisations despite optimal medical treatment
  • Is losing muscle and bone mass due to chronic illness
  • Can no longer work or manage basic daily activities
  • Has a predicted survival of less than two to three years without transplantation

They reflect the point at which the risks of surgery are outweighed by the certainty of deterioration without it.

Not everyone is suitable. Factors that may preclude transplantation include:

  • Active smoking or recent substance use
  • Uncontrolled or active infection
  • Significant dysfunction of other organs, such as the kidneys or heart
  • Certain active malignancies
  • Severe psychological instability that would affect post-transplant adherence

Every case is assessed individually by the best lung transplant doctors in Navi Mumbai at UMC Hospitals.

Before a patient is listed, a comprehensive workup is completed. This includes:

  • Pulmonary function tests and the six-minute walk test
  • High-resolution CT chest and VQ scan
  • Right heart catheterisation and echocardiogram
  • Nutritional and physiotherapy assessment
  • Psychological evaluation

This isn't bureaucratic box-ticking. Each test answers a specific question about whether the patient can survive the surgery and recover from it.

Once listed, patients in India are registered with the regional or national organ allocation network. Waiting times vary - weeks to months, sometimes longer. During this period:

  • The patient's condition is monitored closely and optimized
  • Pulmonary rehabilitation continues
  • Nutrition is managed carefully
  • Some patients require bridging support with ECMO, extracorporeal membrane oxygenation, if they deteriorate while waiting

Donor matching considers blood group compatibility, body size, and lung dimensions. The donor lungs must fit the recipient's chest cavity; a mismatch of more than 20% in predicted total lung capacity is generally not acceptable.

On transplant day, timing is everything. Donor lungs remain viable for roughly four to six hours after procurement. The procedure involves:

  • Opening the chest and removing the diseased lung
  • Connecting the donor lung to the recipient's bronchus, pulmonary artery, and pulmonary veins
  • Cardiopulmonary bypass or ECMO support is used during the procedure if needed
  • Post-operatively, the patient spends one to three weeks in the ICU with close monitoring.

Recovery then involves:

  • Chest physiotherapy and graded exercise programme
  • Regular spirometry to track lung function
  • Bronchoscopy at intervals to assess the airways and detect early rejection
  • Lifelong immunosuppressive medications - non-negotiable, as stopping them risks rejection of the donor lung

Recovery extends over several months. It is gradual, and progress varies from patient to patient.

This journey is as emotionally demanding as it is physical. Patients often carry guilt that a donor's death has given them life. Families carry anxiety through the waiting period and beyond. Psychological support, offered before and after transplantation, is not optional. It is part of the care. Lung transplantation offers something close to a second life, and that, in our experience, makes every complexity of this process worth it.

Our lung transplant programme brings together an experienced multidisciplinary team, including pulmonologists, thoracic surgeons, cardiologists, intensivists, physiotherapists, and transplant coordinators, working in close coordination at every stage. From pre-transplant evaluation and waitlist management to surgery, ICU recovery, and long-term follow-up, care is structured, continuous, and personalized. As one of the best lung transplant hospitals in Navi Mumbai, UMC Hospital is supported by advanced respiratory diagnostics, ECMO capability, and dedicated psychological support.